- Title
- COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
- Creator
- Tomlinson, I. P. M.; Dunlop, M.; Aaltonen, L. A.; Hemminki, K.; Lindblom, A.; Forsti, A.; Sieber, O.; Lipton, L.; van Wezel , T.; Morreau, H.; Wijnen, J. T.; Devilee, P.; Campbell, H.; Scott, R.; Zanke, B.; Gallinger, S.; Hudson, T.; Koessler, T.; Pharoah, P. D.; Niittymakix, I.; Tuupanenx, S.
- Relation
- British Journal of Cancer Vol. 102, p. 447-454
- Publisher Link
- http://dx.doi.org/10.1038/sj.bjc.6605338
- Publisher
- H. K. Lewis
- Resource Type
- journal article
- Date
- 2009
- Description
- It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
- Subject
- colorectal cancers; polymorphisms; associations
- Identifier
- http://hdl.handle.net/1959.13/808968
- Identifier
- uon:7800
- Identifier
- ISSN:0007-0920
- Language
- eng
- Reviewed
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